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The dropouts of the participants at each efficacy interval may be considered the weakness of this trial that was due to COVID-19 lockdown. The benefits are backed by over a decade of clinical research, summarized as follows. Int J Dent. When you recommend Colgate Sensitive Pro Relief, you can help your dentin hypersensitivity patients to enjoy a pain-free life, confident in the knowledge that youre providing a highly effective, evidence-based solution. Provided by the Springer Nature SharedIt content-sharing initiative. J Dent Probl Solut. 1. IADR, The Excel, United Kingdom. These then interact to form a complex with positive charge. [32] reported statistically significant improvement in mechanical stimulated DH with Pro-argin immediately after topical application relative to 8% strontium Acetate in 2016. it is in a rubbish bin now. Moreover, FCPS as a new bioactive material revealed promising potency of sustainable management of DH in a previously conducted trial by Ashwini et al. Hence, the current study outcomes, along with previously published findings, corroborate the in vitro findings of obliteration of dentinal tubules with strontium acetate impeding painful fluid movement in dentine [29]. A meta-analysis by Matranga et al. Balevi B. YYYY Colgate-Palmolive Company. Moreover, there was no significant difference between dentifrices containing FCPS, Pro-argin, and 8% strontium acetate (p>0.05) on completion of trial after six weeks. blokerer jeblikkeligt smerter fra isninger. However, Pro-argin formulation showed 8% more improvement in clinical symptoms of DH than strontium acetate formulation one minute after application. Blocks the pain of sensitive teeth. Soft tissues were isolated with cotton rolls, and adjacent teeth were isolated with cotton pellets. was used for statistical analysis. 2017;30(4):2216. Clinical efficacy of BioMin F, Colgate sensitive pro-relief and Sensodyne rapid action dentifrices in DH [Internet]. Colgate Sensitive Instant Relief Whitening Toothpaste 75 ml Pack of 5, Blocks Pain Instantly, Prevents Sensitivity, Gently Removes Stains (5 x 75 ml) 1,230 5 offers from 12.50 Colgate Sensitive Pro Relief Enamel Repair Toothpaste 75ml - 4 packs 94 22 offers from 14.14 Colgate Sensitive Instant Relief Enamel Repair Toothpaste 75 ml 190 2016;36(3):4403. The sensitive toothpaste remineralises tooth enamel for more resistance against acid attacks. in 2019 using BioMin F and Pro-argin. The price for Colgate Sensitive Pro-Relief is set at RM12.80 to avoid being categorized at RM13.00. With regular use, it reduces teeth sensitivity and helps to strengthen gums and prevent gum recession. HOW LONG CAN A PATIENT USE Colgate SENSITIVE INSTANT Relief Repair & Prevent? Today's era of flourishing research in DH is based on incorporating bioactive ingredients in commercially available oral dentifrices that can induce deep intratubular remineralisation of dental hard tissues for permanent or long-term treatment purposes. Felix J, Ouanounou A. Dentin hypersensitivity: etiology, diagnosis, and management. 2013;41(2):18794. Directions for Use: For instant relief, apply directly to the sensitive tooth with finger tip and massage gently for 1 minute, up to twice a day and for children 6-12 years once a week or less frequently. Post-hoc analysis revealed a significant reduction in DH scores in treatment arms compared to control on completing the six-week trial (p<0.05). It improves gum health and helps reduce factors that contribute to gum recession, a leading cause of tooth sensitivity. 2010;23(Spec No A):14A-9A. J Clin Periodontol. https://doi.org/10.17352/2394-8418.00003. Dentin hypersensitivity is characterized by a short, sharp pain arising from open dentin tubules in exposed dentin in response to external stimuli, which cannot be attributed to any other defect or disease. A systematic review. For instant relief, just apply directly to the sensitive tooth with finger tip and gently massage for one minute. PubMed Sealed channels protect against pain caused by hot, cold and sweet stimuli. SCASS and VAS were introduced on each visit as primary and secondary outcome measures, respectively. Provides 24/7 sensitivity protection. The treatment difference between Pro-argin and 8% strontium acetate was not statistically significant with a p>0.05 for immediate and sustained pain relief in DH and statistically significant relative to control on all clinical parameters of the SCASS and VAS. Therefore, it was considered to be rejected at a p valueof 0.05. The effect of the incorporation of fluoride into strontium containing bioactive glasses. 2023 BioMed Central Ltd unless otherwise stated. found the clinical efficacy of Pro-argin better than strontium acetate for mechanical and air-blast stimulated DH on VAS and SCASS in follow-up periods of one minute, three days, two, four and eight weeks in a systematic review in 2015. BMC Oral Health 21, 498 (2021). Dentinal tubules occluded by bioactive glass-containing toothpaste exhibit high resistance toward acidic soft drink challenge. Follow the directions for use. Product Benefits. In our study, patient compliance related to the recommended time of application and method of the application provided by doctors was controlled by subjecting multiple efficacy intervals and different methods for assessment of the change in pain scores due to DH. Pro-Argin technology helps to seal and repair . The formula consists of Arginine, an amino acid naturally found in saliva and also calcium from calcium carbonate. PubMed Central Listing a study does not mean it has been evaluated by the U.S. Federal Government. The mean scores with repeated measures were statistically analysed at each time point for study outcomes. All the treatment groups subjected to testing in the present study revealed a considerable clinically significant symptomatic reduction in DH relative to the pre-treatment condition that was also statistically significant. Dentine tubule occlusion by novel bioactive glass-based toothpastes. It is clinically proven for instant and lasting Sensitivity relief* How does it work? BMC Oral Health Helps repair teeth by forming a mineral layer that re-constructs the sensitive part of the tooth, with regular use; Seals the open nerve channels for instant relief, and helps prevent sensitivity from re-occurring; Plus the freshness you trust from Colgate 2019;88:103170. J Oral Sci. However, Pro-argin showed more clinical improvement in air blast and mechanically stimulated DH compared to 8% strontium acetate, as shown in Tables 4 and 5. fluorides, arginine, strontium, and bioactive glasses (BAG) [4] and in-office application of bioactive formulations such as glutaraldehyde, resin-based bonding agents and restorative materials, amorphous calcium phosphate based-tooth mousse, and lasers in the dental clinics [5]. Width 17 Height 5 Depth 3.8 Show More Payment & Refunds See patient relevant information on Colgate.com. Significantly greater sensitivity reduction with twice - daily brushing compared to control toothpaste with potassium ions. Therefore, the first null hypothesis was that mean scores for pain due to DH among different treatment groups for immediate relief remain. The burden of dentine hypersensitivity. Friedman Test was used to observe post-application change in treatment responses within the group for 6weeks. Correspondence to Madurai: Best Dental Science College; 2020. The next study outcome of our study wasrelated to 8% strontium acetate with clinical reduction of 37.6% on SCASS and 46% on VAS from baseline using mechanical and water jet stimuli immediately after topical application on sensitive teeth as depicted in Tables 3, 5, and 6. The loss of tooth enamel is the most common cause of tooth sensitivity and is not affected by cavities, gum disease, or other problems. Modified bass brushing method was demonstrated on the same model before the first application of dentifrices in the dental clinic. Lavender SA, Petrou I, Heu R, Stranick MA, Cummins D, Kilpatrick-Liverman L, et al. YES Somewhat No Gillam D, Hill R, Samueli A. Bioactive glasses in the management of dentine hypersensitivity: a review. Mantzourani M, Sharma D. Dentine sensitivity: past, present and future. J Clin Dent. Participants were recalled at interim efficacy intervals of three days, two weeks, four weeks, and six weeks for assessment of sustained relief. Cite this article. For best performance, keep cap closed when not in use. Baseline scores were recorded to measure the intensity of pain due to DH on SCASS with scores2 [22] against air blast stimulus with a triple syringe of the dental unit and on a linear VAS of 10cm length with scores4cm [23], against mechanical stimulus with a dental probe and water jet stimulus with a triple syringe. However, we can conclude that both Pro-argin and strontium acetate-based dentifrices disrupt the pathophysiology of DH and are effective for immediate pain relief even one minute after application on sensitive teeth. Work with Colgate Professional to help provide better oral care to your patients. reporting the instant relief from DH by 44.1% with Pro-argin on SCASS. All rights reserved. Schiff T, Delgado E, Zhang Y, Cummins D, DeVizio W, Mateo L. Clinical evaluation of the efficacy of an in-office desensitizing paste containing 8% arginine and calcium carbonate in providing instant and lasting relief of dentin hypersensitivity. Colgate SENSITIVE INSTANT Relief Repair & Prevent toothpaste with PRO-ARGIN Technology and Zinc provides clinically proven instant* and lasting sensitivity relief1-2 plus lasting gum protection3. WHAT IS THE FLUORIDE CONTENT OF Colgate SENSITIVE INSTANT Relief Repair & Prevent TOOTHPASTE? Exclusive Pro-Argin formula. Panagakos F, Schiff T, Guignon A. Dentin hypersensitivity: effective treatment with an in-office desensitizing paste containing 8% arginine and calcium carbonate. Directions *For instant relief, apply directly to the sensitive tooth with fingertip, and massage gently for 60 seconds, one a week or less frequently **For lasting relief, apply to a gentle toothbrush making sure to brush all sensitive areas of the teeth. Colgate Sensitive Pro-Relief toothpastes have been formulated to provide instant and lasting relief from the pain associated with sensitive teeth. Dentine hypersensitivity. Arginine, Calcium Carbonate, Aqua, Sorbitol, Aroma, Poloxamer 407, Sodium Monofluorophosphate, Cocamidopropyl betaine, Zinc oxide, Benzyl Alcohol, Cellulose Gum, Zinc Citrate, Sodium Bicarbonate, Tetrasodium Pyrophosphate, Xantham Gum, Sodium Saccharin, Sucralose, Limonene, CL77891, 1. 2016;8:114. Gently and effectively removes stains. The clinical significance of this study can be highlighted by the fact that this was a person-centred clinical trial where patients were the prime focus where thepatients suffering from DH. Two double-blind randomized clinical studies by Nathoo et al. However, FCPS formulation showed 1% more improvement than Pro-argin and 7% more than strontium acetate-based dentifrices. Dent Health Curr Res. Internal report 2018, 5. Colgate Sensitive Pro Relief Enamel Repair to strengthen weakened enamel and prevent enamel loss. Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion: an eight-week clinical study on Canadian adults. The participants with self-reported sensitivity in teeth were clinically diagnosed with DH. We found more change in pain scores of VAS used for mechanical stimuli with Pro-argin than FCPS as shown in Table 5 that could be relatable with a randomised controlled trial of FCPS and arginine based desensitizers reporting better treatment response of arginine than FCPS in the cold stimulated DH after two weeks to one month, subsequently [40]. Manage cookies/Do not sell my data we use in the preference centre. These findings were similar to a previous study conducted by Schiff et al. SJAZ has contributed to the conception, design, interpretation of results and critically revised the manuscript. 5 Hines D et al. Children 6 years and younger: use a pea-sized amount for supervised tooth brushing to minimise swallowing. For instant relief, just apply directly to the sensitive tooth with finger tip and gently massage for one minute. Colgate Sensitive Pro-Relief Instant Relief works as a shield that blocks pathways to pain instantly. For children 6-12 years of age, once a week or less frequently. Customers also search toothpaste colgate sensitive colgate enamel colgate pro relief colgate pain relief However, they also suggested further comparative evaluations of two dentifrices with large sample sizes as limited scientific evidence was found in previous studies [16]. 3 Report Deon Hines-0003, 2016. Another . Mockdeci H, Polonini H, Martins I, Granato A-P, Raposo N. Evaluation of ex vivo effectiveness of commercial desensitizing dentifrices. SEALS & REPAIRS: Pro-Argin technology helps to seal and repair the sensitive areas of teeth. Colgate Total with stannous fluoride also offers more benefits than ever before, including sensitivity relief, improved enamel strength* and odor neutralization* (*based on in vitro studies).Colgate Total Advanced Whitening is a tooth whitening toothpaste that provides stain removal and prevention. Colgate Sensitive Pro-Relief r en tandkrm som ger omedelbar och varaktig lindring mot ilningar i tnderna. For lsting relief, apply to a gentle toothbrush making sure to brush all . Dentifrices-containing Pro-argin showed a significant reduction in DH with mean scores of (3.052.17) followed by strontium acetate (3.751.97) followed by FCPS (5.301.83) one minute after application. J Clin Dent. Google Scholar. 2 Docimo et al. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. This clinical trial was not funded by any agency in public, commercial or not-for-profit sectors. California Privacy Statement, J Dent. 2018;9(3):3306. statement and Contemp Clin Dent. In each study, a single fingertip application of Colgate Sensitive Pro Relief was found to provide significant immediate relief relative to the comparative toothpaste, a result that was maintained over the subsequent three days with twice-daily brushing with the same toothpaste. The second objective of the current study was to directly compare the clinical efficacy of FCPS, Pro-argin technology, and strontium acetate-based dentifrices due to their similar mode of action and tubular occluding potential in managing DH [36, 37]. Colgate Sensitive Pro Relief Teeth Whitening Sensitivity Toothpaste, 75ml 4.9 out of 5 stars 12 7 offers from SAR 33.95 Colgate Sensitive Pro Relief Base Instant Sensitivity Relief Toothpaste, 75ml 4.3 out of 5 stars 20 5 offers from SAR 31.25 Colgate Total 12 hour Protection Pro - Gum Health Toothpaste 75ml Akber A, Ali NS, Shabbir S, Wahid U, Farooqui WA. Bae J-H, Kim Y-K, Myung S-K. Desensitizing toothpaste versus placebo for dentin hypersensitivity: a systematic review and meta-analysis. This clinical trial has not included a run-in or washout period before the test phase due to time constraints and compliance of the potential participants. Article Brush twice daily. Plus it has the freshness you trust from Colgate! Am J Dent. This study investigated the relief from pain in DH in one minute after applying over the counter (OTC) dentifrices with Pro-Argin and strontium acetate and directly compared them with fluoro-calcium phospho-silicate (FCPS)-based dentifrices for immediate and sustained inhibition of painful stimulus provoking DH. Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste for the daily oral care of patients with dentine hypersensitivity and gum problems. Colgate Sensitive Pro Relief Multi Protection, offering all of the above benefits in one convenient formula. Douglas-de-Oliveira DW, Vitor GP, Silveira JO, Martins CC, Costa FO, Cota LOM. J Clin Periodontol. Hu M-L, Zheng G, Zhang Y-D, Yan X, Li X-C, Lin H. Effect of desensitizing toothpastes on dentine hypersensitivity: a systematic review and meta-analysis. Amsterdam: Elsevier; 2015. p. 4576. Ayad F, Ayad N, Zhang YP, DeVizio W, Cummins D, Mateo LR. Compend Contin Educ Dent. Colgate Sensitive Pro-Relief Complete Protection sensitivity toothpaste is clinically proven for instant and lasting relief from sensitivity pain. Samueli A, Hill R, Gillam D. Bioactive glasses in the management of dentine hypersensitivity: a review. Use regularly to enjoy long-lasting relief from sensitivity*. 1):8A-15A. Thank you for your feedback. The prevalence of DH was found to vary from about 5 to 62% owing to the use of different diagnostic and measuring tools and age groups in the published literature, with the best average estimate of 34% worldwide [3]. & Farooqui, W.A. Pro-Argin technology provides instant* and long-lasting, Oral Care Products | Colgate Professional. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. J Clin Dent 20 (2009), special issue 123-130, 2. Mahmoodi B, Wood R, Cook R. Protection and acid resistivity of bioactive-glasses, arginine and calcium silicate. West N, Newcombe RG, Hughes N, Mason S, Maggio B, Sufi F, et al. The second null hypothesis was that mean scores for pain due to DH among different treatment groups for sustained relief remains the same, and it was considered to be rejected at a p value0.05. 2020;12(2):87. 3rd edition, Public Health England 2014. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. 2016;3(1):0504. Ingredients *Potassium Nitrate No adverse events like gingival inflammation, bad taste, allergies, fluoride incompatibility, and dental or tongue stains were observed for all dentifrices. Then, the repeated measure was obtained after five minutes for previous pain recovery, and dentifrices were provided to the patient for self-application. Colgate Sensitive Pro-Relief works by plugging the channels to block tooth sensitivity and with regular use, it builds a long-lasting protective barrier that acts like a seal against sensitivity. It is clinically proven for instant and lasting Sensitivity relief* How does it work? observed a significantly greater reduction in sensitivity from air and tactile stimuli when compared to a potassium ion toothpaste, an effect sustained at two, four and eight weeks of use. For patients in the dental chair, it can be used to rapidly ease hypersensitivity pain, facilitate examinations and make dental procedures more comfortable. Written consent was obtained from all participants to participate in the six-week clinical trial. Network meta-analysis on the effect of desensitizing toothpastes on dentine hypersensitivity. A randomised clinical trial on the efficacy of 5% fluorocalcium phosphosilicate-containing novel bioactive glass toothpaste. FCPS showed the highest reduction in DH on SCASS and VAS for waterjet stimuli with mean scores of (0.970.68) (1.801.73) and Pro-Argin on VAS for mechanical stimuli with mean scores of (2.151.92) in six weeks. Mintsmak. CONSORT flow chart. Grnberg C, Bauer F, Crispin A, Jakob M, Hickel R, Draenert ME. Pro-Argin showed a greater reduction in DH with mean scores of (1.340.68) (4.201.70) (3.052.17) followed by strontium acetate (1.570.81) (4.651.87) (3.751.97) on SCASS and VAS for mechanical and water jet stimuli, one minute after application. (Table 1) (Fig. Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste for the daily oral care of patients with dentine hypersensitivity and gum problems. 1Intervention for Group A denotes BioMin F. 2Intervention for Group B denotes Colgate Sensitive Pro relief. Colgate Sensitive Pro Relief can be applied directly to the affected area for almost instant relief. 6 Ipsos, Romania Patient Experience Programme on Colgate SENSITIVE PRO-Relief, results collected after 2-week trial, 545 respondents, 2015. To alleviate their tooth sensitivity problem, by using Colgate Sensitive Pro-Relief will give them lasting relief and they can drink ice water freely. Google Scholar. If symptoms persist, talk to your healthcare professional. Klubpris: 25,46 kr. J Clin Exp Dent. No side effects, apart from money not well spent. # In-vitro study, actual confocal images after 5 treatments. Therefore, in the current study, we used a dental explorer and the air blast and water jet stimuli from the triple syringe of the dental unit for testing DH to control the subjective variations in treatment response. All rights reserved. 2017;2017:2. We provided oral hygiene instructions and ways of relieving their pain from DH to improve their quality of life. This toothpaste really does not help at all with symptoms of sensitive teeth. Identifier NCT 04249336. Venkataramana S, Jeyaraman SK, Kothimbakkam SSK, Chellathurai BNK. Poster #3406, July 2018 IADR. The study's primary objective was to investigate pain relief in one minute after topical application of Pro-argin and strontium acetate on sensitive teeth in DH. Favaro Zeola L, Soares PV, Cunha-Cruz J. Individuals either with dental caries, heavily restored, or cracked teeth, or with orthodontic or prosthetic appliances, or with localised or generalised gingivitis or pulpitis and heavy calculus or using any desensitising toothpaste or mouth wash or any other desensitising products up to six weeks before the study were excluded from this trial. Comparative efficacy of BioMin-F, Colgate Sensitive Pro-relief and Sensodyne Rapid Action in relieving dentin hypersensitivity: a randomized controlled trial. Frequency of dentin hypersensitivity: a cross-sectional study. The widely accepted hydrodynamic theory proposes that stimuli can alter the behavior of fluid in the dentin tubules, activating intra-dental nerve fibers and causing pain. Pessoa, Loretto et al. Canines and premolars are the most commonly affected teeth among 2530% of the adult population [2]. 2015;42(2):13141. 75 ml. Dentin hypersensitivity can have significant detrimental effects on your patients wellbeing and quality of life. A total of 140 met the eligibility criteria with at least two sensitive teeth anterior to molars due to erosions or abrasions with or without an associated gingival recession. Colgate Sensitive Pro-Relief works by plugging the channels to block tooth sensitivity and with regular use, it builds a long-lasting protective barrier that acts like a seal against sensitivity. Colgate Sensitive Instant Relief Toothpaste starts blocking sensitivity pain instantly*. Nathoo S, Delgado E, Zhang YP, DeVizio W, Cummins D, Mateo LR: Comparing the efficacy in providing instant relief of dentine hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchmark desensitizing toothpaste containing 2% potassium ion and 1450 ppm fluoride and to a control toothpaste with 1450 ppm fluoride: A three-day clinical study in New Jersey, USA. Wilcoxon Signed-Rank Test was used to compute mean scores relative to baseline at each time point. Lai et al. Benefits: Colgate Sensitive Prevent and Repair is clinically proven to provide superior relief vs Sensodyne Extra Whitening at 8 weeks1 Long-lasting relief from hypersensitivity with continued use Superior sensitivity relief at 8 weeks vs the leading Sensodyne toothpaste variant 1 Anvnd tv gnger dagligen. Was this answer helpful? They explored greater tubular occlusion potential and more acid resistance of Pro-argin in comparison to FCPS after subsequent seven days of application on dentinal discs [38]. The findings have revealed that both statistically and clinically significant change in mean scores of DH was observed with Pro-argin and 8% strontium acetate with p<0.05 relative to baseline for immediate and sustained relief from DH using clinical parameters of SCASS and VAS. Saba Arshad. PREVENTS SENSITIVITY COMING BACK: Sealed channels protect against pain for instant relief, and with regular use provide lasting protection to prevent sensitivity from . 2010;21(2):428. Oral Care Products | Colgate Professional, Colgate Toothpaste - Dentists & Patients | Colgate Professional, Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste, Instantly* relieves dentine hypersensitivity, Long-lasting relief from the pain of sensitive teeth, Helps strengthen gums and prevent gum recession, Recommended fluoride level for caries protection (1450ppm). It contains clinically proven Pro-Argin technology which provides instant and lasting sensitivity relief. Desensitizing toothpastes for dentin hypersensitivity: a network meta-analysis.

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