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2010;66(2):127-136. Patients with medium-chain acyl-coenzyme a dehydrogenase deficiency have impaired oxidation of fat during exercise but no effect of L-carnitine supplementation. Mate, A., Miguel-Carrasco, J. L., Monserrat, M. T., and Vazquez, C. M. Systemic antioxidant properties of L-carnitine in two different models of arterial hypertension. View abstract. It seemed to get me fairly wired. Yet, there are a few known side effects that include agitation, insomnia and nausea. Ann.Nutr.Metab 2008;53(2):91-95. Dal Lago A, De Martini D, Flore R, et al. Clin Endocrinol (Oxf) 2016;84(6):851-7. It can also cause the urine, breath, and sweat to have a "fishy" odor. View abstract. Pola P, Tondi P, Dal Lago A, and et al. View abstract. If given to patients on dialysis, 3 or more grams of L-carnitine daily might cause hypercalcaemia. A healthy individual can also produce sufficient amounts within the body. 2009;9:53. Santo, S. S., Sergio, N., Luigi, D. P., Giuseppe, M., Margherita, F., Gea, O. C., Roberto, F., Gabriella, C., Giuseppe, P., and Massimiliano, A. Mintz M. Carnitine in human immunodeficiency virus type 1 infection/acquired immune deficiency syndrome. View abstract. Effects of L-carnitine administration on left ventricular remodeling after acute anterior myocardial infarction: the L-Carnitine Ecocardiografia Digitalizzata Infarto Miocardico (CEDIM) Trial. Int J Clin Pharmacol Res 1990;10(1-2):81-84. View abstract. Int J Clin Pharmacol Ther Toxicol. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. The early effects of intravenous L-propionyl carnitine on ulcerative trophic lesions of the lower limbs in arteriopathic patients: a controlled randomized study. Protective role of carnitine in breast cancer via decreasing arginase activity and increasing nitric oxide. Metabolism 2007;56(8):1118-1123. Neurology 1991;41:1726-32. Taking L-carnitine by, High levels of cholesterol or other fats (lipids) in the blood (, Conditions in a male that prevent a female partner from. Hlais, S., Reslan, D. R., Sarieddine, H. K., Nasreddine, L., Taan, G., Azar, S., and Obeid, O. Ann.Pharmacother. Here are several other types of carnitine: For most people, acetyl-L-carnitine and L-carnitine seem to be the most effective for general use. View abstract. Effect of L-carnitine on the limitation of infarct size in one-month postmyocardial infarction cases. Carnitine, valproate, and toxicity. 2008;107(2):139-144. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. View abstract. 2010;9(3):265-268. J Nutr.Biochem. PLoS One. View abstract. In specific cases, this form may even protect your brain from cell damage. Use of a long-chain triglyceride-restricted/medium-chain triglyceride-supplemented diet in a case of malonyl-CoA decarboxylase deficiency with cardiomyopathy. Ho, J. Y., Kraemer, W. J., Volek, J. S., Fragala, M. S., Thomas, G. A., Dunn-Lewis, C., Coday, M., Hakkinen, K., and Maresh, C. M. l-Carnitine l-tartrate supplementation favorably affects biochemical markers of recovery from physical exertion in middle-aged men and women. Clin Nephrol. Rev.Salud Publica (Bogota.) View abstract. Zhang JJ, Wu ZB, Cai YJ, Ke B, Huang YJ, Qiu CP, Yang YB, Shi LY, Qin J. L-carnitine ameliorated fasting-induced fatigue, hunger, and metabolic abnormalities in patients with metabolic syndrome: a randomized controlled study. Italian Study Group on Carnitine and Male Infertility. View abstract. Pastoris, O., Dossena, M., Foppa, P., Catapano, M., Arbustini, E., Bellini, O., Dal Bello, B., Minzioni, G., Ceriana, P., and Barzaghi, N. Effect of L-carnitine on myocardial metabolism: results of a balanced, placebo-controlled, double-blind study in patients undergoing open heart surgery. The effect of L-carnitine (carnitene) on myocardial metabolism of patients with coronary artery disease. Pharmacol Rev 2002;54:589-98. Winter SC, Szabo-Aczel S, Curry CJR, et al. View abstract. Naito J, Ohashi H, Ohno M, et al. Note: This document contains side effect information about levocarnitine. Tanphaichitr N. In vitro stimulation of human sperm motility by acetylcarnitine. View abstract. [Short-term medication of L-carnitine before intracytoplasmic sperm injection for infertile men with oligoasthenozoospermia]. Pettegrew JW, Klunk WE, Panchalingam K, et al. 2020;39(5):457-468. Taking L-carnitine with thyroid hormone might decrease the effectiveness of the thyroid hormone. Pesce, V., Fracasso, F., Cassano, P., Lezza, A. M., Cantatore, P., and Gadaleta, M. N. Acetyl-L-carnitine supplementation to old rats partially reverts the age-related mitochondrial decay of soleus muscle by activating peroxisome proliferator-activated receptor gamma coactivator-1alpha-dependent mitochondrial biogenesis. View abstract. Wadman, R. I., Bosboom, W. M., van der Pol, W. L., van den Berg, L. H., Wokke, J. H., Iannaccone, S. T., and Vrancken, A. F. Drug treatment for spinal muscular atrophy types II and III. Cochrane.Database.Syst.Rev. Editorial comment on: Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study. Rossle, C., Pichard, C., Roulet, M., Chiolero, R., Schutz, Y., Temler, E., Schindler, C., Zurlo, F., Jequier, E., and Furst, P. [Effect of L-carnitine supplemented total parenteral nutrition on postoperative lipid and nitrogen utilization]. View abstract. DiMauro, S. and Hirano, M. Mitochondrial DNA Deletion Syndromes. Eur J Urol 1996;30(Suppl 2):954. Malaguarnera, M., Vacante, M., Motta, M., Giordano, M., Malaguarnera, G., Bella, R., Nunnari, G., Rampello, L., and Pennisi, G. Acetyl-L-carnitine improves cognitive functions in severe hepatic encephalopathy: a randomized and controlled clinical trial. Effect of L-carnitine on human immunodeficiency virus-1 infection-associated apoptosis: a pilot study. [v] View abstract. Gunal, A. I., Celiker, H., Donder, E., and Gunal, S. Y. The effect of combined L-carnitine and erythropoietin administration on the anaemia and on the lipid profile of patients on hemodialysis [abstract]. 3. View abstract. View abstract. Acta Urol Ital 1996;10(3):185-187. A., Cotman, C. W., and Sullivan, P. G. Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging. View abstract. Malaguarnera, M., Gargante, M. P., Russo, C., Antic, T., Vacante, M., Malaguarnera, M., Avitabile, T., Li, Volti G., and Galvano, F. L-carnitine supplementation to diet: a new tool in treatment of nonalcoholic steatohepatitis--a randomized and controlled clinical trial. Grandis, D. D. Tolerability and efficacy of L-acetylcarnitine in patients with peripheral neuropathies: a short-term, open multicentre study. The effect of enteral carnitine administration in humans. Acta Paediatr Hung 1986;27:253-8. 1992;14(4):183-194. View abstract. View abstract. BJU Int 2002;89:895-900. 2010;33(2):132-136. View abstract. One study of people with type 2 diabetes taking anti-diabetic medication indicated that carnitine supplements significantly reduced blood sugar levels, compared to a placebo (55). HIV.Med. Insomnia (unable to sleep). View abstract. A case of hemoperfusion and L-carnitine management in valproic acid overdose. Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, DiDonato JA, Chen J, Li H, Wu GD, Lewis JD, Warrier M, Brown JM, Krauss RM, Tang WH, Bushman FD, Lusis AJ, Hazen SL. Hamedi-Kalajahi F, Zarezadeh M, Mojtahedi SY, Shabbidar S, Fahimi D, Imani H. Effect of L-carnitine supplementation on lipid profile and apolipoproteins in children on hemodialysis: a randomized placebo-controlled clinical trial. Fertil.Steril 2003;80(Suppl 3):48. Segura-Bruna, N., Rodriguez-Campello, A., Puente, V., and Roquer, J. Valproate-induced hyperammonemic encephalopathy. The mitochondria act as engines within your cells, burning these fats to create usable energy. This may lead to irritability, hyperactivity or insomnia. View abstract. Bonavita E, Bertuzzi D, Bonavita J, and et al. Malaguarnera, M., Vacante, M., Motta, M., Malaguarnera, M., Li, Volti G., and Galvano, F. Effect of L-carnitine on the size of low-density lipoprotein particles in type 2 diabetes mellitus patients treated with simvastatin. J Neurol.Sci 3-15-2004;218(1-2):103-108. 2002;4(1):61-66. Cochrane Database Syst Rev. View abstract. Rossini, P. M., Marchionno, L., Gambi, D., Pirchio, M., Del Rosso, G., and Albertazzi, A. EMG changes in chronically dialyzed uraemic subjects undergoing d, 1- Carnitine treatment. Enhancement of activities relative to fatty acid oxidation in the liver of rats depleted of L-carnitine by D-carnitine and a gamma- butyrobetaine hydroxylase inhibitor. Cao, Y., Wang, Y. X., Liu, C. J., Wang, L. X., Han, Z. W., and Wang, C. B. Novak M, Monkus EF, Buch M, and et al. Sproule, D. M., Dyme, J., Coku, J., de, Vinck D., Rosenzweig, E., Chung, W. K., and De Vivo, D. C. Pulmonary artery hypertension in a child with MELAS due to a point mutation of the mitochondrial tRNA((Leu)) gene (m.3243A > G). View abstract. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to levocarnitine: injectable solution, oral capsule, oral solution, oral tablet. View abstract. Jimenez Caballero, P. E. and Marsal, Alonso C. [Type 1 glutaric aciduria: clinical and therapeutic implications]. Nootropics are drugs or supplements that can boost brain function. Effect of propionyl-L-carnitine, L-arginine and nicotinic acid on the efficacy of vardenafil in the treatment of erectile dysfunction in diabetes. Version: 1.03. Rare side effects can include muscle weakness in uremic patients and seizures in people with seizure disorders. Mantovani, G., Maccio, A., Madeddu, C., Gramignano, G., Serpe, R., Massa, E., Dessi, M., Tanca, F. M., Sanna, E., Deiana, L., Panzone, F., Contu, P., and Floris, C. Randomized phase III clinical trial of five different arms of treatment for patients with cancer cachexia: interim results. Bjornsson, E. Hepatotoxicity associated with antiepileptic drugs. Cancer Chemother Pharmacol 1999;44:170-2. View abstract. Jpn Heart J 1982;23(3):349-359. Loffredo, L., Marcoccia, A., Pignatelli, P., Andreozzi, P., Borgia, M. C., Cangemi, R., Chiarotti, F., and Violi, F. Oxidative-stress-mediated arterial dysfunction in patients with peripheral arterial disease. Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer's dementia. An analysis of 3 multicenter studies and a bibliographic review]. View abstract. View abstract. Clin Ther 2012;34(8):1674-1682. Latifian S, Hamdi K, Totakneh R. Effect of addition of l-carnitine in polycystic ovary syndrome (PCOS) patients with clomiphene citrate and gonadotropin resistant. Benton, D. and Donohoe, R. T. The influence on cognition of the interactions between lecithin, carnitine and carbohydrate. 1980;4(1):23-34. Abdollahi H, Abdolahi M, Sedighiyan M, Jafarieh A. View abstract. View abstract. 1992;140(4):353-377. View abstract. Cherchi A, Lai C, Onnis E, et al. Cardiovasc.Drugs Ther 1999;13:537-46. Clin Drug Invest 1996;11(2):90-96. Immunopharmacol.Immunotoxicol. View abstract. OTHER NAMES(S): 3-carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminiu, OTHER NAME(S): 3-carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminiu, L-carnitine is a chemical that is made in the human. 2011;31(5):376-377. Int J Clin Pharmacol Res 1995;15:9-15. If you do not have a dose-measuring device, ask your pharmacist for one. Caruso U, Cravotto E, Tisone G, and et al. Crill, C. M., Storm, M. C., Christensen, M. L., Hankins, C. T., Bruce, Jenkins M., and Helms, R. A. Carnitine supplementation in premature neonates: effect on plasma and red blood cell total carnitine concentrations, nutrition parameters and morbidity. Int.J Sport Nutr.Exerc.Metab 2008;18(1):19-36. A., and Greenhaff, P. L. Increasing muscle carnitine content alters muscle fuel metabolism and improves exercise performance in humans. Ann N Y Acad Sci 2004;1033:30-41. Kahn J, Lagakos S, Wulfsohn M, et al. This thread is archived Since L-carnitine helps move more fatty acids into your cells to be burned for energy, you might think this would increase your ability to burn fat and lose weight. View abstract. View abstract. View abstract. Weinhandl, E. D., Rao, M., Gilbertson, D. T., Collins, A. J., and Pereira, B. J. "Product Information. Clin J Am Soc Nephrol. L-carnitine supplementation of a soybean-based formula in early infancy: plasma and urine levels of carnitine and acylcarnitines. In some people, carnitine can cause fishy body odor, abdominal cramps, nausea, vomiting, muscle weakness, rash, increases in appetite, diarrhea or body odor, especially with the high doses found in supplements. View abstract. 2007;12 Suppl 1:43-51. View abstract. 2006;176(4 Pt 1):1307-1312. 2016;39(6):277-80.View abstract. View abstract. Gheissari A, Aslani N, Eshraghi A, et al. View abstract. Zhonghua Nan.Ke.Xue. J Am Med Assoc 1999;282:2305-12. It can also cause a "fishy" odor of the urine, breath, and sweat. 2013 May;19(5):576-85. 1992;141(11):379-384. You can get small amounts of L-carnitine from your diet by eating meat and fish (4, 5). View abstract. Ann.Pharmacother. Nutrients 2018;10(2). Wang, J. and Wang, X. Int J Clin Pharmacol Res 1988;8(5):367-376. J Int.Soc.Sports Nutr. View abstract. View abstract. Biolo, G., Stulle, M., Bianco, F., Mengozzi, G., Barazzoni, R., Vasile, A., Panzetta, G., and Guarnieri, G. Insulin action on glucose and protein metabolism during L-carnitine supplementation in maintenance haemodialysis patients. Chan, A., Remington, R., Kotyla, E., Lepore, A., Zemianek, J., and Shea, T. B. 2005;28(2):141-152. View abstract. Because carnosine can lower blood pressure, individuals with already low blood pressure should exercise extra caution when taking it . 2011;17(7):H55-H59. Park, H. D., Kim, S. R., Ki, C. S., Lee, S. Y., Chang, Y. S., Jin, D. K., and Park, W. S. Two novel HADHB gene mutations in a Korean patient with mitochondrial trifunctional protein deficiency. Golper, T. A., Wolfson, M., Ahmad, S., Hirschberg, R., Kurtin, P., Katz, L. A., Nicora, R., Ashbrook, D., and Kopple, J. D. Multicenter trial of L-carnitine in maintenance hemodialysis patients. View abstract. Effects of parenteral L-carnitine supplementation on fat metabolism and nutrition in premature neonates. As a supplement, acetyl-L-carnitine is usually considered safe when taken as directed. Lynch, K. E., Feldman, H. I., Berlin, J. Rausch CR, Paul S, Marx KR, et al. 2010;20(6):711-723. Acetyl-l-carnitine: a pathogenesis based treatment for HIV-associated antiretroviral toxic neuropathy. J Am Coll Cardiol 1995;26:1411-6. View abstract. A. However, there were some mild side effects, including nausea and stomach discomfort (24, 58). Eat these 11 foods to boost your memory and focus, help prevent disease, and keep sharp as you. Sawicka AK, Hartmane D, Lipinska P, Wojtowicz E, Lysiak-Szydlowska W, Olek RA. Hsieh, C. T., Hwu, W. L., Huang, Y. T., Huang, A. C., Wang, S. F., Hu, M. H., and Chien, Y. H. Early detection of glutaric aciduria type I by newborn screening in Taiwan. View abstract. (pre-publication author's copy, via correspondence) 2002;1-14. The safety and efficacy of adefovir dipivoxil, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults: a randomized, double-blind, placebo-controlled trial. Am.J Clin Oncol. Pediatr Res 1984;18:815-9. There are few negative side effects from this supplement at reasonable doses. 2006;30(5):421-425. DiNicolantonio, J. J., Lavie, C. J., Fares, H., Menezes, A. R., and O'Keefe, J. H. L-carnitine in the secondary prevention of cardiovascular disease: systematic review and meta-analysis. Int Urol Nephrol 2021;53(10):2149-2158. View abstract. Cipolli, C. and Chiari, G. [Effects of L-acetylcarnitine on mental deterioration in the aged: initial results]. It is well-known that insomnia often occurs in the setting of various social stressors (e.g., personal loss, social disruption), mental and physical health problems (e.g., heart disease, depression) and in those with a family history of the condition (see Risk Factors for Insomnia ). Yano J, Kaida Y, Maeda T, et al. Hollyer T, Boon H, Georgousis A, et al. View abstract. L-carnitine is best known as a fat burner but the overall research is mixed. Med.Sci Sports Exerc. View abstract. Cochrane.Database.Syst.Rev. JPEN J Parenter.Enteral Nutr 1988;12(6):555-562. Metabolism Boosters: Weight Loss Fact or Fiction? Ishikura H, Matsuo N, Matsubara M, et al. In: Pagon, R. A., Bird, T. D., Dolan, C. R., Stephens, K., and Adam, M. P. GeneReviews [Internet]. Braz.J Med.Biol.Res. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Penn, D., Schmidt-Sommerfeld, E., and Wolf, H. Carnitine deficiency in premature infants receiving total parenteral nutrition. Heinonen OJ. L-Carnitine Supplement Side Effects. 4-5-2008;130(12):441-445. Multicenter trial of L-carnitine in maintenance hemodialysis patients. Adding L-carnitine to clomiphene resistant PCOS women improves the quality of ovulation and the pregnancy rate. [Efficacy of natural vitamin E on oligospermia and asthenospermia: a prospective multi-centered randomized controlled study of 106 cases]. Cifone MG, Alesse E, Di Marzio L, et al. Zhonghua Nei Ke.Za Zhi. Cai, H., Yi, W., Li, M., and et al. View abstract. Plasma carnitine deficiency: Clinical observations in 51 pediatric patients. 2010;16(1):5-14. Current Therapeutic Research 1989;46(6):1027-1033. Bijarnia, S., Wiley, V., Carpenter, K., Christodoulou, J., Ellaway, C. J., and Wilcken, B. Glutaric aciduria type I: outcome following detection by newborn screening. Kavukcu, S., Turkmen, M., Salman, S., Onvural, B., Oktay, G., Karaman, O., and Cevik, N. T. The effects of L-carnitine on respiratory function tests in children undergoing chronic hemodialysis. Perez-Oliva, J. F., Guillen, Y., Gutierrez, F., and Parodis, Y. FDA. Eur.Urol. Eur J Clin Pharmacol 2019;75(8):1037-46. doi: 10.1007/s00228-019-02666-5. Askarpour M, Hadi A, Miraghajani M, Symonds ME, Sheikhi A, Ghaedi E. Beneficial effects of l-carnitine supplementation for weight management in overweight and obese adults: An updated systematic review and dose-response meta-analysis of randomized controlled trials. Boneh, A., Beauchamp, M., Humphrey, M., Watkins, J., Peters, H., and Yaplito-Lee, J. Call your doctor at once if you have: Common side effects of L-Carnitine may include: This is not a complete list of side effects and others may occur. Fortin, G., Yurchenko, K., Collette, C., Rubio, M., Villani, A. C., Bitton, A., Sarfati, M., and Franchimont, D. L-carnitine, a diet component and organic cation transporter OCTN ligand, displays immunosuppressive properties and abrogates intestinal inflammation. This article examines the potential risks and benefits of L-carnitine supplements and explains how this nutrient functions in your body. View abstract. [Ref], There have been reports from clinical trials of significant increases in platelet aggregation associated with high doses of levocarnitine (the active ingredient contained in L-Carnitine) (3 g/day) given to hemodialysis patients. El Sharkwy I, Sharaf El-Din M. l-Carnitine plus metformin in clomiphene-resistant obese PCOS women, reproductive and metabolic effects: a randomized clinical trial. Ann N Y Acad Sci 2004;1033:158-67. . Andrologia 1994;26(3):155-159. Jpn J Clin Pharmacol Ther 1989;20(3):607-618. Nephron 1991;57(3):306-313. J Eur Acad Dermatol Venereol. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Eur Heart J 1989;10(6):502-508. Eur J Gastroenterol Hepatol 2019;31(7):878-84. doi: 10.1097/MEG.0000000000001368. 2008;26(3):388-4. Am J Dis Child 1987;141:660-5. View abstract. View abstract. Lee, N. C., Tang, N. L., Chien, Y. H., Chen, C. A., Lin, S. J., Chiu, P. C., Huang, A. C., and Hwu, W. L. Diagnoses of newborns and mothers with carnitine uptake defects through newborn screening. L-carnitine might increase the effects of acenocoumarol and increase the chance of bruising and bleeding. Yet, there are a few known side effects that include agitation, insomnia and nausea. Castro-Gago M, Eiris-Punal J, Novo-Rodriguez MI, et al. Thomas, S., Fischer, F. P., Mettang, T., Pauli-Magnus, C., Weber, J., and Kuhlmann, U. 12-3-1999;87(4):366-368. 2007;21(1):259-264. Am.J Alzheimers.Dis Other Demen. Calabrese, V., Cornelius, C., Stella, A. M., and Calabrese, E. J. Brevetti, G., di Lisa, F., Perna, S., Menabo, R., Barbato, R., Martone, V. D., and Siliprandi, N. Carnitine-related alterations in patients with intermittent claudication: indication for a focused carnitine therapy. Wall, B. T., Stephens, F. B., Constantin-Teodosiu, D., Marimuthu, K., Macdonald, I. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. Sabba, C., Berardi, E., Antonica, G., Ferraioli, G., Buonamico, P., Godi, L., Brevetti, G., and Albano, O. 1998;32(2):258-264. 2010;93(6):1907-1910. Zhang, Y., Song, J. Q., Liu, P., Yan, R., Dong, J. H., Yang, Y. L., Wang, L. F., Jiang, Y. W., Zhang, Y. H., Qin, J., and Wu, X. R. [Clinical studies on fifty-seven Chinese patients with combined methylmalonic aciduria and homocysteinemia]. Di Cesare Mannelli L, Ghelardini C, Calvani M, et al. 2010;34(3):295-299. Cardiology 2006;106(4):215-223. Donnelly, C. T., Hameed, A. 2010;16(10):919-921. Other research reveals that acetyl-L-carnitine may also help boost brain health and function as you age (64, 65). Clin Nutr 2012;31(2):176-182. Korean J.Nutrition 2007;40(7):630-638. Cruciani, R. A., Dvorkin, E., Homel, P., Culliney, B., Malamud, S., Lapin, J., Portenoy, R. K., and Esteban-Cruciani, N. L-carnitine supplementation in patients with advanced cancer and carnitine deficiency: a double-blind, placebo-controlled study. Even though the chance of adverse side effects is slight, there are two things that we suggest when taking Coenzyme Q10. Xie, J., Zeng, Q., and Wang, L. The protective effect of L-carnitine on ischemia-reperfusion heart. View abstract. Pacheco, A., Torres, R., Sanhueza, M. E., Elgueta, L., Segovia, E., and Cano, M. [Study of aerobic capacity in chronic hemodialized patients: effect of L-carnitine supplementation]. View abstract. Efficacy of L-propionylcarnitine treatment in patients with left ventricular dysfunction. 1996;208(3):129-134. Suchitra, M. M., Ashalatha, V. L., Sailaja, E., Rao, A. M., Reddy, V. S., Bitla, A. R., Sivakumar, V., and Rao, P. V. The effect of L-carnitine supplementation on lipid parameters, inflammatory and nutritional markers in maintenance hemodialysis patients. 2006;39(4):465-474. Zelnik N, Fridkis I, Gruener N. Reduced carnitine and antiepileptic drugs: cause relationship or co-existence? Xie, H., Tang, S. Y., Li, H., Luo, X. H., Yuan, L. Q., Wang, D., and Liao, E. Y. L-carnitine protects against apoptosis of murine MC3T3-E1 osteoblastic cells. View abstract. View abstract. Nephron 38 (1984): 120-4, 6. Penn, D., Schmidt-Sommerfeld, E., and Pascu, F. Decreased tissue carnitine concentrations in newborn infants receiving total parenteral nutrition. Oncologist. Cellular stress responses, mitostress and carnitine insufficiencies as critical determinants in aging and neurodegenerative disorders: role of hormesis and vitagenes. View abstract. Kidney Int 1990;38:912-8. It has been reported to cause vomiting, diarrhea, a fishy body odor, abdominal cramps, and nausea. View abstract. Volek, J. S., Judelson, D. A., Silvestre, R., Yamamoto, L. M., Spiering, B. Chazot, C., Blanc, C., Hurot, J. M., Charra, B., Jean, G., and Laurent, G. Nutritional effects of carnitine supplementation in hemodialysis patients. View abstract. Mar.Drugs 2009;7(1):57-70. Medicine (Baltimore). Malaguarnera, M., Gargante, M. P., Cristaldi, E., Colonna, V., Messano, M., Koverech, A., Neri, S., Vacante, M., Cammalleri, L., and Motta, M. Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue. 1987;24(1):23-28. Pediatr.Nephrol. View abstract. Signorelli, S. S., Fatuzzo, P., Rapisarda, F., Neri, S., Ferrante, M., Oliveri, Conti G., Fallico, R., Di, Pino L., Pennisi, G., Celotta, G., and Massimiliano, A. 2005;59(4):592-596. Acta Neurol.Scand. View abstract.

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does l carnitine cause insomnia

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